Harry (Chriss Lee) is a young, Jewish scientist who lives with his overprotective and overbearing mother, Ida (Victoria Barkoff). He spends most of his time in his laboratory trying to isolate the guilt gene, using live rats for his tests.

When the laboratory administration announces a major budget cut, he can no longer afford the number of rats he needs to continue his research. But Harry does not despair; he finds an agency that supplies rats from Transylvania at a very low price. When he is bitten by one of these specimens, his quiet life takes quite a radical turn…

Henceforth, Harry undergoes a nightly transformation into Draghoula, a vampire in drag who roams the streets in search of fresh, human blood. This daily metamorphosis does not go unnoticed by Harry’s mother, nor his co-worker, Sabrina (Stephanie Seidle), who is secretly in love with him. Convinced they are each the only ones that hold the key to returning Harry to his original state, they both set out, in turn, to save him.